Senior Research Associate
Virginia Bioinformatics Institute

Assistant Professor, Affiliate
Department of Mathematics
 
Virginia Tech
Blacksburg, VA 24061

Tel: 540-231-9456
Fax: 540-231-2606
ajarrah@vbi.vt.edu


Professional Preparation:

  • Ph.D., Mathematics, New Mexico State University, 2002.
  • M.S., Mathematics, Yarmouk University, Jordan, 1995.
  • B.S., Mathematics and Computer Science, Yarmouk University, Jordan, 1992.


Current Research Interests:

  • Computational Algebra,  
  • Finite Dynamical Systems,
  • Computational Systems Biology,
  • Computational Immunology,
  • Reverse Engineering Gene Regulatory Networks,
  • Mathematical Modeling and Simulation,
  • The interplay between the structure of a network and its dynamics.

My research interests are rooted in computational systems biology. To be precise, I am interested in developing, implementing, and using mathematical methods for the modeling and simulation of biological systems. Inferring gene regulatory networks from high throughput data and modeling different aspect of the immune system are at the heart of my current research projects.

Using methods from computational algebra and finite dynamical systems, we are developing algorithms for the inference of gene regulatory networks as discrete-time, finite-space dynamical systems which include Boolean networks. Understanding the interplay between the dynamics (e.g., equilibrium points) and structure (such as feedback loops) of a network is essential for identifying the network and constraining its dynamics. We are currently studying this interplay for some classes of systems. The mathematical areas we use in this long term project include computational algebra, finite dynamical systems, discrete mathematics, combinatorics, and agent-based simulations.

The modeling and simulation of the immune system and the many biochemical pathways involved in its response have been the focus of my research projects. I was a member of a team that developed agent-based models of the immune system response to Epstein-Barr virus infection. Currently, in collaboration with three labs here at Virginia Tech, I am leading the modeling effort of three research projects related to immune system. Namely, we are developing a mathematical model of the immune system response in the early onset of the Duchenne muscular dystrophy disease (with Prof. Grange’s Lab), a mathematical model of obesity-related inflammation  (with Prof. Bassaganya-Riera’s Lab), and a mathematical model of the differentiation of macrophages (with Prof. Li’s Lab).


Last Updated: December 31, 2008.

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